Dura mater has significant impact on traumatic brain mechanobiology and injury. However, dura mater is neglected in numerical and physical head models. The lack of site specific morpho-mechanical data of dura may be considered a critical rationale behind this simplification. This study aimed to assess how location-dependent mechanical anisotropy is linked to principal collagen fiber orientation. Stress and stretch at failure, elastic modulus, and a microstructurally motivated material model were integrated to examine local differences in morpho-mechanics. A non-symmetrical fiber dispersion material model fits the data well and offers a comprehensive parameter base for further studies and finite element models.